Channelpedia

PubMed 17070524


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.1 , Kv1.2 , Kv1.5



Title: The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae.

Authors: Yousra Abdel-Mottaleb, Elke Clynen, Amir Jalali, Frank Bosmans, Hossein Vatanpour, Liliane Schoofs, Jan Tytgat

Journal, date & volume: FEBS Lett., 2006 Nov 13 , 580, 6254-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17070524


Abstract
The very first member of K(+) channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically. OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as alpha-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K(+) channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183+/-3 nM but did not affect any of the other channels.