Referenced in: none

Automatically associated channels: Kv1.2

Title: Cloning and modulation by endothelin-1 of rat cardiac K channel.

Authors: K Ishii, K Nunoki, H Murakoshi, N Taira

Journal, date & volume: Biochem. Biophys. Res. Commun., 1992 May 15 , 184, 1484-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1590805

Abstract
We have cloned a delayed rectifier type K channel from rat heart (RH1). RH1 was identical to the rat brain K channel BK2 and differed from recently cloned rat cardiac K channel RAK by one amino acid residue. Endothelin receptors(ETRs)-mediated modulation of RH1 current (IRH1) was studied using Xenopus oocyte expression system. Activation of two different subtypes of ETRs by endothelin-1 equally suppressed the amplitude of IRH1. Stimulation of phosphatidylinositol turnover will probably be responsible for the suppression.