Channelpedia

PubMed 7890032


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir2.3 , Kv1.1 , Kv1.2 , Kv1.4 , Kv1.5 , Kv2.1



Title: Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium.

Authors: K Majumder, M De Biasi, Z Wang, B A Wible

Journal, date & volume: FEBS Lett., 1995 Mar 13 , 361, 13-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/7890032


Abstract
We report the cloning and functional expression of a novel K+ channel beta-subunit from human atrium, hKv beta 3. hKv beta 3 is highly homologous to the two beta-subunits cloned from rat brain, Kv beta 1 and Kv beta 2, but has an essentially unique stretch of 79 N-terminal residues. Upon expression in Xenopus oocytes, hKv beta 3 accelerates the inactivation of co-injected hKv1.4 currents and induces fast inactivation of non-inactivating co-injected hKv1.5 currents. By contrast, hKv beta 3 had no effect on hKv1.1, hKv1.2, or hKv2.1 currents. Thus, hKv beta 3 represents a third type of K+ channel beta-subunit which modulates the kinetics of a unique subset of channels in the Kv1 subfamily.