Channelpedia

PubMed 11527374


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir2.3 , Kv1.2 , SK2



Title: OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus.

Authors: E E Dudina, Y V Korolkova, N E Bocharova, S G Koshelev, T A Egorov, I Huys, J Tytgat, E V Grishin

Journal, date & volume: Biochem. Biophys. Res. Commun., 2001 Sep 7 , 286, 841-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11527374


Abstract
A novel inhibitor of voltage-gated K(+) channels has been purified to homogeneity from the venom of the black scorpion Orthochirus scrobiculosus. This toxin, named OsK2, has been characterized as a 28-residue peptide, containing six conserved cysteine residues and was shown to be a potent and selective blocker of Kv1.2 channels (K(d) = 97 nM). OsK2 is the second member of the 13th subfamily of short-chain K(+) channel-blocking peptides known thus far and is therefore called alpha-KTx 13.2.