Referenced in: none

Automatically associated channels: Kv1.2

Title: Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes.

Authors: M P Kavanaugh, M J Christie, P B Osborne, A E Busch, K Z Shen, Y N Wu, P H Seeburg, J P Adelman, R A North

Journal, date & volume: Biochem. J., 1991 Aug 1 , 277 ( Pt 3), 899-902

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1651707

Abstract
Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.