Channelpedia

PubMed 22882011


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.2



Title: Chukrasones A and B: potential Kv1.2 potassium channel blockers with new skeletons from Chukrasia tabularis.

Authors: Hong-Bing Liu, Hua Zhang, Ping Li, Zhao-bing Gao, Jian-Min Yue

Journal, date & volume: Org. Lett., 2012 Sep 7 , 14, 4438-41

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22882011


Abstract
Two new limonoids, chukrasone A (1) incorporating a highly rearranged A/B ring system and chukrasone B (2) possessing the first 16,19-dinor limonoid backbone with an extended C3 unit at C-15, were isolated from Chukrasia tabularis. Their structures were characterized on the basis of detailed spectroscopic analysis. Compounds 1 and 2 exhibited potential inhibition of the delayed rectifier (I(K)) K(+) current.