Channelpedia

PubMed 10624965


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.1 , Kv1.2



Title: Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.

Authors: S Poliak, L Gollan, R Martinez, A Custer, S Einheber, J L Salzer, J S Trimmer, P Shrager, E Peles

Journal, date & volume: Neuron, 1999 Dec , 24, 1037-47

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10624965


Abstract
Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that this neurexin-like protein and the closely related molecule Caspr/Paranodin demarcate distinct subdomains in myelinated axons. While contactin-associated protein (Caspr) is present at the paranodal junctions, Caspr2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. We further show that Caspr2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. This association involves the C-terminal sequence of Caspr2, which contains a putative PDZ binding site. These results suggest a role for Caspr family members in the local differentiation of the axon into distinct functional subdomains.