Channelpedia

PubMed 8587873


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.2 , Kv3.1



Title: Microheterogeneity in heteromultimeric assemblies formed by Shaker (Kv1) and Shaw (Kv3) subfamilies of voltage-gated K+ channels.

Authors: M Shahidullah, N Hoshi, S Yokoyama, H Higashida

Journal, date & volume: Proc. Biol. Sci., 1995 Sep 22 , 261, 309-17

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8587873


Abstract
Single K+ channels were recorded in Xenopus oocytes injected with a 1:1 mixture of mRNAs coding for NGK1 (Kv1.2) and NGK2 (Kv3.1a) voltage-dependent K+ channels. A new class of channels of 18 pS conductance was observed, and was designated as NGK1,2 channels. According to their properties of activation voltages and open life times, four types of NGK1,2 channels with microheterogeneity were detected. The results suggest that voltage-dependent NGK1 Shaker and NGK2 Shaw K+ channels, from different subfamilies, assemble to form heteromultimeric K+ channels, giving rise to a mosaic of characteristics inherited from two parental channels.