Referenced in: none

Automatically associated channels: Kv1.2 , Kv1.6

Title: Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.

Authors: C Antozzi, C Frassoni, A Vincent, M C Regondi, F Andreetta, P Bernasconi, C Ciano, T Chang, F Cornelio, R Spreafico, R Mantegazza

Journal, date & volume: Neurology, 2005 Apr 12 , 64, 1290-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15824370

Abstract
A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. Stiff-person syndrome was absent, but fast blink reflex recovery suggested enhanced brainstem excitability. The range of antibodies produced in thymoma-associated neuromyotonia is richer, and the timing of antibody appearance more complex, than previously suspected.