Referenced in: none

Automatically associated channels: Kv1.2

Title: Kv1.2 potassium channel inhibitors from Chukrasia tabularis.

Authors: Hong-Bing Liu, Hua Zhang, Ping Li, Yan Wu, Zhao-bing Gao, Jian-Min Yue

Journal, date & volume: Org. Biomol. Chem., 2012 Feb 21 , 10, 1448-58

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22215113

Abstract
Eighteen new limonoids, chubularisins A-R (1-18), along with eleven known analogues, were isolated from the stem bark of Chukrasia tabularis. The structures of 1-18 were elucidated on the basis of spectroscopic data and chemical evidence. Compound 1 represented the first example of 8,9,12-orthoester of phragmalin limonoids. Interestingly, compounds 4, 8, and 22 exhibited potent and selective inhibition against the delayed rectifier (I(K)) K(+) current with IC(50) values of 0.61, 2.03, and 2.15 μM, respectively.