Channelpedia

PubMed 26657556


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1 , TRPM , TRPM8 , TRPV , TRPV1



Title: TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.

Authors: Shijia Chen, Cindy N Chiu, Kimberly L McArthur, Joseph R Fetcho, David A Prober

Journal, date & volume: Nat. Methods, 2016 Feb , 13, 147-50

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26657556


Abstract
The zebrafish (Danio rerio) is a useful vertebrate model system in which to study neural circuits and behavior, but tools to modulate neurons in freely behaving animals are limited. As poikilotherms that live in water, zebrafish are amenable to thermal and pharmacological perturbations. We exploit these properties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal populations using the chemical and thermal agonists of heterologously expressed TRPV1, TRPM8 and TRPA1.