Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM8

Title: Regulation of TRPM8 channel activity.

Authors: Yevgen Yudin, Tibor Rohacs

Journal, date & volume: Mol. Cell. Endocrinol., 2012 Apr 28 , 353, 68-74

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22061619

Abstract
Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca(2+) permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a well established sensor of environmental cold temperatures, found in peripheral sensory neurons, where its activation evokes depolarization and action potentials. The activity of TRPM8 is regulated by a number of cellular signaling pathways, most notably by phosphoinositides and the activation of phospholipase C. This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways.