Channelpedia

PubMed 24278689


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPM7 , TRPM8



Title: TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets.

Authors: Nelson S Yee, Ada S Chan, Julian D Yee, Rosemary K Yee

Journal, date & volume: Scientifica (Cairo), 2012 , 2012, 415158

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24278689


Abstract
Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer.