Channelpedia

PubMed 21841075


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPM8



Title: A cool channel in cold transduction.

Authors: Ramon Latorre, Sebastian Brauchi, Rodolfo Madrid, Patricio Orio

Journal, date & volume: Physiology (Bethesda), 2011 Aug , 26, 273-85

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21841075


Abstract
Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological role, and near-membrane trafficking of this exciting polymodal ion channel.