Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM8

Title: Distribution of transient receptor potential melastatin-8-containing nerve fibers in rat oral and craniofacial structures.

Authors: Takehiro Yajima, Tadasu Sato, Hiroshi Hosokawa, Teruyoshi Kondo, Masahiro Saito, Hidetoshi Shimauchi, Hiroyuki Ichikawa

Journal, date & volume: Ann. Anat., 2015 Sep , 201, 1-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25978347

Abstract
The transient receptor potential melastatin-8 (TRPM8) is a cold and menthol receptor located in the sensory ganglia. Immunohistochemistry for TRPM8 was performed on oral and craniofacial structures of the rat. TRPM8-immunoreactive (-IR) nerve fibers were detected in the oral mucous membrane. In the gingiva, TRPM8-IR nerve fibers were abundant beneath and within crestal and outer epithelia. Such nerve fibers were also common beneath and within taste buds in the incisive papilla. In addition, TRPM8-immunoreactivity was expressed by some taste bud cells in the papilla. Lips, periodontal ligaments and salivary glands as well as masticatory muscles and temporomandibular joints were mostly devoid of TRPM8-IR nerve fibers. A double immunofluorescence study indicated different distribution patterns of nerve fibers containing TRPM8 and calcitonin gene-related peptide in oral and craniofacial tissues. Retrograde tracing method also indicated that TRPM8-IR nerve fibers in the gingiva and incisive papilla originate from small sensory neurons in the trigeminal ganglion. TRPM8 may be associated with cool, cold nociceptive (<around 25°C) and chemoreceptive transmission in the oral mucosa.