Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC6 , TRPM , TRPM8 , TRPV , TRPV2 , TRPV6

Title: TRP channels in prostate cancer: the good, the bad and the ugly?

Authors: Dimitra Gkika, Natalia Prevarskaya

Journal, date & volume: Asian J. Androl., 2011 Sep , 13, 673-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21623387

Abstract
During the last decade, transient receptor potential (TRP) channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 (TRPM8), TRP vanilloid 6 (TRPV6),TRP canonical (TRPC6) and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.