Channelpedia

PubMed 23993334


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1 , TRPM , TRPM8



Title: 3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Authors: Giorgio Ortar, Aniello Schiano Moriello, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo, Luciano De Petrocellis

Journal, date & volume: Bioorg. Med. Chem. Lett., 2013 Oct 15 , 23, 5614-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23993334


Abstract
Following the recent identification of the naturally occurring 3-ylidene-4,5-dihydrophthalide ligustilide and its oxidation product dehydroligustilide as novel TRPA1 modulators, a series of seventeen 3-ylidenephthalides was synthesized and tested on TRPA1 and TRPM8 channels. Most of these compounds acted as strong modulators of the two channel types with EC50 and/or IC50 values distinctly lower than those of the reference compounds.