Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM8

Title: Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.

Authors: Raul R Calvo, Sanath K Meegalla, Daniel J Parks, William H Parsons, Shelley K Ballentine, Mary Lou Lubin, Craig Schneider, Raymond W Colburn, Christopher M Flores, Mark R Player

Journal, date & volume: Bioorg. Med. Chem. Lett., 2012 Mar 1 , 22, 1903-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22330635

Abstract
Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described.