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PubMed 24165912


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Automatically associated channels: Kir2.3 , TRP , TRPM , TRPM8



Title: Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.

Authors: Jiang He, Tanika N Kelly, Qi Zhao, Hongfan Li, Jianfeng Huang, Laiyuan Wang, Cashell E Jaquish, Yun Ju Sung, Lawrence C Shimmin, Fanghong Lu, Jianjun Mu, Dongsheng Hu, Xu Ji, Chong Shen, Dongshuang Guo, Jixiang Ma, Renping Wang, Jinjin Shen, Shengxu Li, Jing Chen, Hao Mei, Chung-Shiuan Chen, Shufeng Chen, Jichun Chen, Jianxin Li, Jie Cao, Xiangfeng Lu, Xigui Wu, Treva K Rice, C Charles Gu, Karen Schwander, L Lee Hamm, Depei Liu, Dabeeru C Rao, James E Hixson, Dongfeng Gu

Journal, date & volume: Circ Cardiovasc Genet, 2013 Dec , 6, 598-607

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24165912


Abstract
Blood pressure (BP) responses to dietary sodium and potassium intervention and cold pressor test vary considerably among individuals. We aimed to identify novel genetic variants influencing individuals' BP responses to dietary intervention and cold pressor test.We conducted a genome-wide association study of BP responses in 1881 Han Chinese and de novo genotyped top findings in 698 Han Chinese. Diet-feeding study included a 7-day low-sodium (51.3 mmol/d), a 7-day high-sodium (307.8 mmol/d), and a 7-day high-sodium plus potassium supplementation (60 mmol/d). Nine BP measurements were obtained during baseline observation and each intervention period. The meta-analyses identified 8 novel loci for BP phenotypes, which physically mapped in or near PRMT6 (P=7.29 × 10(-9)), CDCA7 (P=3.57 × 10(-8)), PIBF1 (P=1.78 × 10(-9)), ARL4C (P=1.86 × 10(-8)), IRAK1BP1 (P=1.44 × 10(-10)), SALL1 (P=7.01 × 10(-13)), TRPM8 (P=2.68 × 10(-8)), and FBXL13 (P=3.74 × 10(-9)). There was a strong dose-response relationship between the number of risk alleles of these independent single-nucleotide polymorphisms and the risk of developing hypertension during the 7.5-year follow-up in the study participants. Compared with those in the lowest quartile of risk alleles, odds ratios (95% confidence intervals) for those in the second, third, and fourth quartiles were 1.39 (0.97, 1.99), 1.72 (1.19, 2.47), and 1.84 (1.29, 2.62), respectively (P=0.0003 for trend).Our study identified 8 novel loci for BP responses to dietary sodium and potassium intervention and cold pressor test. The effect size of these novel loci on BP phenotypes is much larger than those reported by the previously published studies. Furthermore, these variants predict the risk of developing hypertension among individuals with normal BP at baseline.