Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM8

Title: Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8.

Authors: Willy Carrasquel-Ursulaez, Hans Moldenhauer, Juan Pablo Castillo, Ramon Latorre, Osvaldo Alvarez

Journal, date & volume: Temperature (Austin), 2015 Apr-Jun , 2, 188-200

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27227023

Abstract
Mammals maintain homeostatic control of their body temperature. Therefore, these organisms are expected to have adaptations that confer the ability to detect and react to both self and ambient temperature. Temperature-activated ion channels have been discovered to be the primary molecular determinants of thermosensation. The most representative group of these determinants constitutes members of the transient receptor potential superfamily, TRP, which are activated by either low or high temperatures covering the whole range of physiologically relevant temperatures. This review makes a critical assessment of existing analytical methods of temperature-activated TRP channel mechanisms using the cold-activated TRPM8 channel as a paradigm.