Referenced in: none

Automatically associated channels: K2P , TREK1

Title: The role of the potassium channel gene KCNK2 in major depressive disorder.

Authors: Chiara Congiu, Alessandra Minelli, Cristian Bonvicini, Marco Bortolomasi, Riccardo Sartori, Carlo Maj, Catia Scassellati, Giuseppe Maina, Luigi Trabucchi, Matilde Segala, Massimo Gennarelli

Journal, date & volume: Psychiatry Res, 2015 Feb 28 , 225, 489-92

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25535009

Abstract
Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.