PubMed 25535009

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNK , KCNK2

Title: The role of the potassium channel gene KCNK2 in major depressive disorder.

Authors: Chiara Congiu, Alessandra Minelli, Cristian Bonvicini, Marco Bortolomasi, Riccardo Sartori, Carlo Maj, Catia Scassellati, Giuseppe Maina, Luigi Trabucchi, Matilde Segala, Massimo Gennarelli

Journal, date & volume: Psychiatry Res, 2015 Feb 28 , 225, 489-92

PubMed link:

Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.