Channelpedia

PubMed 20823525


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv10.1 , Kv12.1



Title: Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels.

Authors: Ricardo Adaixo, João Henrique Morais-Cabral

Journal, date & volume: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2010 Sep 1 , 66, 1056-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20823525


Abstract
Per-Arnt-Sim (PAS) domains are ubiquitous in nature; they are approximately 130-amino-acid protein domains that adopt a fairly conserved three-dimensional structure despite their low degree of sequence homology. These domains constitute the N-terminus or, less frequently, the C-terminus of a number of proteins, where they exert regulatory functions. PAS-containing proteins generally display two or more copies of this motif. In this work, the crystallization and preliminary analysis of the PAS domains of two eukaryotic potassium channels from the ether-à-go-go (EAG) family are reported.