Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC1 , TRPC4 , TRPC5

Title: The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.

Authors: Hana Kim, Jinsung Kim, Jae-Pyo Jeon, Jongyun Myeong, Jinhong Wie, Chansik Hong, Hyun Jin Kim, Ju-Hong Jeon, Insuk So

Journal, date & volume: Channels (Austin), 2012 Sep-Oct , 6, 333-43

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22878724

Abstract
TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαq protein coupled receptor or epidermal growth factor in particular. However, our understanding of the roles of Gαi/o proteins on TRPC4/5 channels is still rudimentary. We discuss potential roles for Gαi/o proteins in channel activation in addition to their known role in cellular signaling.