PubMed 22878724

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPC , TRPC1 , TRPC4 , TRPC5

Title: The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.

Authors: Hana Kim, Jinsung Kim, Jae-Pyo Jeon, Jongyun Myeong, Jinhong Wie, Chansik Hong, Hyun Jin Kim, Ju-Hong Jeon, Insuk So

Journal, date & volume: Channels (Austin), 2012 Sep-Oct , 6, 333-43

PubMed link:

TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαq protein coupled receptor or epidermal growth factor in particular. However, our understanding of the roles of Gαi/o proteins on TRPC4/5 channels is still rudimentary. We discuss potential roles for Gαi/o proteins in channel activation in addition to their known role in cellular signaling.