Referenced in: none

Automatically associated channels: Slo2

Title: Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.

Authors: Maile R Brown, Jack Kronengold, Valeswara-Rao Gazula, Yi Chen, John G Strumbos, Fred J Sigworth, Dhasakumar Navaratnam, Leonard K Kaczmarek

Journal, date & volume: Nat. Neurosci., 2010 Jul , 13, 819-21

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20512134

Abstract
In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.