Referenced in: none

Automatically associated channels: Slo2

Title: Is Slack an Intrinsic Seizure Terminator?

Authors: Kajsa M Igelström

Journal, date & volume: , 2012 May 29 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22645110

Abstract
Understanding how epileptic seizures are initiated and propagated across large brain networks is difficult, but an even greater mystery is what makes them stop. Failure of spontaneous seizure termination leads to status epilepticus-a state of uninterrupted seizure activity that can cause death or permanent brain damage. Global factors, like changes in neuromodulators and ion concentrations, are likely to play major roles in spontaneous seizure cessation, but individual neurons also have intrinsic active ion currents that may contribute. The recently discovered gene Slack encodes a sodium-activated potassium channel that mediates a major proportion of the outward current in many neurons. Although given little attention, the current flowing through this channel may have properties consistent with a role in seizure termination.