Referenced in: none

Automatically associated channels: Slo2

Title: Targeted treatment of migrating partial seizures of infancy with quinidine.

Authors: David Bearden, Alanna Strong, Jessica Ehnot, Marissa DiGiovine, Dennis Dlugos, Ethan M Goldberg

Journal, date & volume: Ann. Neurol., 2014 Sep , 76, 457-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25042079

Abstract
Migrating partial seizures of infancy is an early onset epileptic encephalopathy syndrome that is typically resistant to treatment. The most common cause is a gain of function mutation in the potassium channel KCNT1. The antiarrhythmic drug quinidine is a partial antagonist of KCNT1 and hence may be a candidate drug for treatment of this condition. We report the case of a child with migrating partial seizures of infancy secondary to an activating mutation in KCNT1 treated with quinidine. Treatment with quinidine was correlated with a marked reduction in seizure frequency and improved psychomotor development.