Referenced in: none

Automatically associated channels: TREK1

Title: [TREK1 potassium channels and depression].

Authors: Dong-Qing Ye, Zhi-jun Zhang, Yang Li

Journal, date & volume: Yao Xue Xue Bao, 2012 Nov , 47, 1403-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23387069

Abstract
Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.