Referenced in: none

Automatically associated channels: TREK1

Title: Activation of TREK-1 by morphine results in analgesia without adverse side effects.

Authors: Maily Devilliers, Jérome Busserolles, Stéphane Lolignier, Emmanuel Deval, Vanessa Pereira, Abdelkrim Alloui, Marine Christin, Bruno Mazet, Patrick Delmas, Jacques Noël, Michel Lazdunski, Alain Eschalier

Journal, date & volume: Nat Commun, 2013 Dec 17 , 4, 2941

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24346231

Abstract
Morphine is the gold-standard pain reliever for severe acute or chronic pain but it also produces adverse side effects that can alter the quality of life of patients and, in some rare cases, jeopardize the vital prognosis. Morphine elicits both therapeutic and adverse effects primarily through the same μ opioid receptor subtype, which makes it difficult to separate the two types of effects. Here we show that beneficial and deleterious effects of morphine are mediated through different signalling pathways downstream from μ opioid receptor. We demonstrate that the TREK-1 K(+) channel is a crucial contributor of morphine-induced analgesia in mice, while it is not involved in morphine-induced constipation, respiratory depression and dependence-three main adverse effects of opioid analgesic therapy. These observations suggest that direct activation of the TREK-1 K(+) channel, acting downstream from the μ opioid receptor, might have strong analgesic effects without opioid-like adverse effects.