Referenced in: none

Automatically associated channels: Kir2.3

Title: Separation of the enantiomers of some potassium channel activators using an alpha 1-acid glycoprotein column.

Authors: J M Evans, R J Smith, G Stemp

Journal, date & volume: J. Chromatogr., 1992 Oct 9 , 623, 163-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1452627

Abstract
The separations of the enantiomers of some 3,4-dihydro-2,2'-dimethyl-2H-1-benzopyrans and a related tetrahydronaphthalene on alpha 1-acid glycoprotein (Chiral-AGP) are presented, together with the results from an investigation of the effects of organic modifier and pH on the separations achieved. The general utility of Chiral-AGP in separating the enantiomers of compounds from this class of antihypertensive agents is demonstrated in this paper.