Referenced in: none

Automatically associated channels: Kv10.1

Title: A subpopulation of bone marrow-derived macrophage-like cells shares a unique ion channel pattern with microglia.

Authors: R B Banati, D Hoppe, K Gottmann, G W Kreutzberg, H Kettenmann

Journal, date & volume: J. Neurosci. Res., 1991 Dec , 30, 593-600

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1724016

Abstract
Rat microglia share a number of antigenic, functional, and morphological similarities with macrophages from other tissues, but are characterized by a distinctly different pattern of ion channels in the cellular membrane (Kettenmann et al., J Neurosci Res 26:278-287, 1990). Macrophages typically express outward and inward K+ currents. In contrast, microglia lack outward currents and only show inwardly rectifying K+ currents, regardless of the isolation or cultivation method employed for microglia. In this study we demonstrate that a subpopulation of bone marrow-derived macrophage-like cells possesses inward rectifier K+ currents, but no outward currents and thus with regard to the electrophysiological characteristics closely resembles microglia. A second population of bone marrow-derived macrophage-like cells shows the usual channel pattern described for other body macrophages. Our results strengthen the hypothesis that in the bone marrow distinct pools of precursor cells exist, possibly reflecting an early differential lineage determination for body and brain macrophages, i.e., microglia.