Referenced in: none

Automatically associated channels: Kv2.1

Title: A heart-like Na+ current in the medial entorhinal cortex.

Authors: J A White, A Alonso, A R Kay

Journal, date & volume: Neuron, 1993 Dec , 11, 1037-47

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8274275

Abstract
Acutely dissociated neurons from the superficial layers of the medial entorhinal cortex of the rat were studied under voltage clamp using the whole-cell patch-clamp configuration. Neurons from the medial entorhinal cortex exhibit a tetrodotoxin (TTX)-resistant Na+ current (ITTX-R; IC50 approximately 146 nM), in addition to the normal TTX-sensitive Na+ current (ITTX-S; IC50 approximately 6 nM). ITTX-R was found in both putative stellate and putative pyramidal neurons from the medial entorhinal cortex. ITTX-R is kinetically indistinguishable from ITTX-S, but can be distinguished from ITTX-S based on its enhanced sensitivity to block by Cd2+, La3+, and Zn2+. ITTX-R is kinetically and pharmacologically similar to the TTX-resistant Na+ current found in cardiac muscle.