Referenced in: none

Automatically associated channels: Kir2.3

Title: Modulation of K(+)-channels in p-neurones of the leech CNS by phosphorylation.

Authors: M Goldermann, W Hanke, W R Schlue

Journal, date & volume: J. Comp. Physiol. A, 1994 Feb , 174, 231-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8145192

Abstract
Two types of potassium channels of identified (p-) neurones of the leech (Hirudo medicinalis) were investigated by using the patch-clamp technique. The open-state probability of these channels in cell-attached patches can be reduced by addition of 5-hydroxytryptamine to the bath solution. After excising the patches the application of alkaline phosphatase to the cytosolic face of the patch increases the open probability. The 5-HT1A-receptor agonist buspirone mimics the effect of 5-HT. Our experiments show that the effect of 5-HT might be due to a channel phosphorylation via a 5-HT1A-receptor subtype.