Referenced in: none

Automatically associated channels: Kir2.3

Title: Ryanodine receptors: how many, where and why?

Authors: V Sorrentino, P Volpe

Journal, date & volume: Trends Pharmacol. Sci., 1993 Mar , 14, 98-103

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8387707

Abstract
Ryanodine receptors are intracellular Ca2+ channels that have been known for more than a decade to have a role in releasing Ca2+ from the sarcoplasmic reticulum to regulate contraction in skeletal and cardiac muscle fibres. Vincenzo Sorrentino and Pompeo Volpe review some recent developments: the ryanodine receptor channels have now been found to be expressed in the central nervous system, and the cloning of a third ryanodine receptor gene (RYR3) has revealed that this new isoform is widely expressed in several tissues and cells. In consequence, the view of ryanodine receptors as Ca2+ channels of muscle cells is rapidly changing, and these channels seem set to take a more central position on the stage of intracellular Ca2+ signalling.