Referenced in: none

Automatically associated channels: Kv10.1

Title: Volume-regulatory taurine release from a human lung cancer cell line. Evidence for amino acid transport via a volume-activated chloride channel.

Authors: K Kirk, J Kirk

Journal, date & volume: FEBS Lett., 1993 Dec 20 , 336, 153-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8262200

Abstract
Exposure of a human lung epithelial cancer cell-line to hypo-osmotic media led to a marked increase in the rate of efflux from the cells of taurine, a non-essential sulfonic amino acid. The osmotically-activated taurine efflux was inhibited by a range of known Cl- channel blockers, the most potent of which were NPPB and 1,9-dideoxyforskolin. These reagents were similarly effective at inhibiting the osmotically-activated efflux of I-, a known substrate of volume-activated Cl- channels. The results are consistent with the hypothesis that volume-regulatory taurine release from these cells is mediated by a volume-activated Cl- channel.