Referenced in: none

Automatically associated channels: Kv10.1

Title: Antibody to the inositol trisphosphate receptor blocks thimerosal-enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs.

Authors: S Miyazaki, H Shirakawa, K Nakada, Y Honda, M Yuzaki, S Nakade, K Mikoshiba

Journal, date & volume: FEBS Lett., 1992 Sep 7 , 309, 180-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1324195

Abstract
The sulfhydryl reagent thimerosal enhanced the sensitivity of hamster eggs to injected inositol 1,4,5-trisphosphate (InsP3) or Ca2+ to generate regenerative Ca2+ release from intracellular pools. A monoclonal antibody (mAb) to the InsP3 receptor blocked both the InsP3-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR). The mAb also blocked Ca2+ oscillations induced by thimerosal. The results indicate that thimerosal enhances IICR sensitized by cytosolic Ca2+, but not CICR from InsP3-insensitive pools, and causes repetitive Ca2+ releases from InsP3-sensitive pools.