Referenced in: none

Automatically associated channels: Kv2.1 , Kv3.4 , Kv4.1

Title: Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21.

Authors: B Rudy, K Sen, E Vega-Saenz de Miera, D Lau, T Ried, D C Ward

Journal, date & volume: J. Neurosci. Res., 1991 Jul , 29, 401-12

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1920536

Abstract
Over ten different mammalian genes related to the Drosophila Shaker gene (the Sh gene family) have been identified recently. These genes encode subunits of voltage-dependent K+ channels. The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively. We report here the cloning of a human K+ channel ShIII cDNA (HKShIIIC) obtained from a brain stem cDNA library. HKShIIIC transcripts express an atypical voltage-dependent transient (A-type) K+ current in Xenopus oocytes. This current is activated by large membrane depolarizations and is extremely sensitive to the K+ channel blocker TEA unlike most A-type currents. The gene encoding HKShIIIC maps to chromosome 1p21.