Referenced in: none

Automatically associated channels: Kv10.1

Title: Pharmacological modulators of the inositol 1,4,5-trisphosphate receptor.

Authors: F Michelangeli, M Mezna, S Tovey, L G Sayers

Journal, date & volume: Neuropharmacology, 1995 Sep , 34, 1111-22

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8532181

Abstract
Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in neuronal function. Some neurotransmitters produce the second messenger InsP3 which activates an intracellular calcium channel (InsP3 receptor) usually located in the endoplasmic reticulum. This article undertakes a comprehensive survey of most pharmacological modulators of the InsP3 receptor so far reported. This review discusses in detail competitive antagonists, non-competitive antagonists and thiol reactive reagents, highlighting their modes of action and in some cases indicating drawbacks in their use.