Referenced in: none

Automatically associated channels: Kir2.3

Title: Ion channels as pharmacologic receptors: the chirality of drug interactions.

Authors: D J Triggle

Journal, date & volume: , 1996 , 8, 35-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8845280

Abstract
Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels.