Referenced in: none

Automatically associated channels: Kv11.1

Title: 1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1.

Authors: Christopher G Barber, David C Blakemore, Jean-Yves Chiva, Rachel L Eastwood, Donald S Middleton, Kerry A Paradowski

Journal, date & volume: Bioorg. Med. Chem. Lett., 2009 Feb 15 , 19, 1075-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19171484

Abstract
The development of a new class of CCR5 antagonist replacing the tropane core of maraviroc by piperidine with a branched N-substituent is described. Compound 15h shows good whole cell antiviral activity together with microsomal stability and only weak activity at the hERG ion channel.