Referenced in: none

Automatically associated channels: Kv2.1

Title: The effects of innervation on the developmental expression of Ca(2+)-activated K+ currents in embryonic parasympathetic neurons are not activity-dependent.

Authors: P Subramony, S E Dryer

Journal, date & volume: Brain Res. Dev. Brain Res., 1996 Jan 22 , 91, 149-52

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8821488

Abstract
Chronic blockade of synaptic transmission in ovo using mecamylamine, a neuronal nicotinic receptor antagonist, caused a large increase in naturally occurring cell death in the embryonic chick ciliary ganglion. However, the Ca(2+)-activated K+ currents in embryonic day 13 mecamylamine-treated ciliary ganglion neurons were indistinguishable from those of saline-treated controls. Therefore, the trophic effect of preganglionic innervation on the developmental expression of Ca(2+)-activated K+ current is not dependent upon intact nicotinic cholinergic synaptic transmission and may instead be mediated by a nerve terminal-derived differentiation factor.