Referenced in: none

Automatically associated channels: Kir2.3 , Kv1.4

Title: Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit.

Authors: S H Heinemann, J Rettig, F Wunder, O Pongs

Journal, date & volume: FEBS Lett., 1995 Dec 27 , 377, 383-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8549760

Abstract
A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.