Referenced in: none

Automatically associated channels: HCN3

Title: The effect of aquaporin 5 overexpression on the Ras signaling pathway.

Authors: Janghee Woo, Juna Lee, Myoung Sook Kim, Se Jin Jang, David Sidransky, Chulso Moon

Journal, date & volume: Biochem. Biophys. Res. Commun., 2008 Mar 7 , 367, 291-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18155156

Abstract
Human aquaporin 5 (AQP5) has been shown to be overexpressed in multiple cancers, such as pancreatic cancer and colon cancer. Furthermore, it has been reported that ectopic expression of AQP5 leads to many phenotypic changes characteristic of transformation. However, the biochemical mechanism leading to transformation in AQP5-overexpressing cells has not been clearly elucidated. In this report, the overexpression of AQP5 in NIH3T3 cells demonstrated a significant effect on Ras activity and, thus, cell proliferation. Furthermore, this influence was shown to be mediated by phosphorylation of the PKA consensus site of AQP5. This is the first evidence demonstrating an association between AQP5 and a signaling pathway, namely the Ras signal transduction pathway, which may be the basis of the oncogenic properties seen in AQP-overexpressing cells.