Referenced in: none

Automatically associated channels: Kv11.1

Title: Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Authors: Takashi Mizutani, Tsuyoshi Nagase, Sayaka Ito, Yasuhisa Miyamoto, Takeshi Tanaka, Norihiro Takenaga, Shigeru Tokita, Nagaaki Sato

Journal, date & volume: Bioorg. Med. Chem. Lett., 2008 Dec 1 , 18, 6041-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18952421

Abstract
Novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives were identified as potent human H(3) receptor inverse agonists. After systematic modification of lead 5a, the potent and selective analog 5r was identified. Elimination of hERG K(+) channel and human alpha(1A)-adrenoceptor activities is the main focus of the present study.