Referenced in: none

Automatically associated channels: Kir2.3

Title: Hypoxia in striatal and cortical neurones: membrane potential and Ca2+ measurements.

Authors: A Pisani, P Calabresi, G Bernardi

Journal, date & volume: Neuroreport, 1997 Mar 24 , 8, 1143-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9175102

Abstract
Simultaneous measurements of membrane potential and intracellular Ca2+ were used to study the effects of hypoxia on striatal and cortical neurones. Striatal neurones responded to hypoxia with a reversible membrane depolarization coupled with a transient increase in intracellular Ca2+. Thirty minutes of hypoxia caused an irreversible membrane depolarization associated with a massive raise in Ca2+ levels, leading to cell death. Conversely, cortical neurones were more resistant to O2 deprivation. Hypoxia (4-10 min) induced minimal changes in both membrane potential and Ca2+ signals. Longer periods (20-30 min) caused an initial membrane hyperpolarization followed by a large but reversible depolarization coupled with a transient increase in Ca2+ signals. These results support the hypothesis of a differential sensitivity of central neurones to hypoxia, suggesting that striatal neurones are more vulnerable than cortical cells.