Referenced in: none

Automatically associated channels: Kir2.3

Title: Binding of neuroligins to PSD-95.

Authors: M Irie, Y Hata, M Takeuchi, K Ichtchenko, A Toyoda, K Hirao, Y Takai, T W Rosahl, T C Südhof

Journal, date & volume: Science, 1997 Sep 5 , 277, 1511-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9278515

Abstract
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.