Referenced in: none

Automatically associated channels: Kir6.2

Title: A touching case of channel regulation: the ATP-sensitive K+ channel.

Authors: S J Tucker, F M Ashcroft

Journal, date & volume: Curr. Opin. Neurobiol., 1998 Jun , 8, 316-20

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9687347

Abstract
The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel.