Referenced in: none

Automatically associated channels: Kir2.3

Title: Vesicular osmometers, vasopression secretion and aquaporin-4: a new mechanism for osmoreception?

Authors: T Wells

Journal, date & volume: Mol. Cell. Endocrinol., 1998 Jan 15 , 136, 103-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9548213

Abstract
This review cites new evidence suggesting a link between the recently discovered membrane bound water-selective channel, aquaporin-4 (AQP4), and the mechanism of central osmoreception. AQP4 is found in a number of brain regions associated with the osmoregulation of vasopressin secretion and thirst, including the supraoptic nucleus (SON) and subfornical organ (SFO). AQP4 expression is restricted to ependymal cell membranes in the SFO and astrocyte membranes in the SON, especially perivascular end foot processes, suggesting that glial cells may correspond to Verney's hypothalamic 'vesicular osmometers'. Information on osmotic status may thus be conveyed to the neuronal elements of the 'osmoreceptor complex' by a neurone-glial interaction.