Referenced in: none

Automatically associated channels: Kir1.1

Title: Regulation of distal nephron K+ channels (ROMK) mRNA expression by aldosterone in rat kidney.

Authors: A H Beesley, D Hornby, S J White

Journal, date & volume: J. Physiol. (Lond.), 1998 Jun 15 , 509 ( Pt 3), 629-34

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9596787

Abstract
1. The expression of ROMK mRNA isoforms in rat kidney was measured using competitive polymerase chain reaction. Under basal conditions the expression of ROMK2 and 3 mRNA was significantly higher than that of ROMK1 or 6. 2. Administration of aldosterone for a period of 1 week significantly increased the mRNA expression not only of the alpha1-subunit of the Na+-K+-ATPase, but also of ROMK2, 3 and 6. 3. These data not only provide evidence that ROMK K+ channels may be involved with mineralocorticoid-sensitive K+ secretion in the distal nephron, but also demonstrate for the first time that ROMK6 may be involved in this process.