Referenced in: none

Automatically associated channels: Cavβ1

Title: Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels.

Authors: K Hogan, R G Greg, P A Powers

Journal, date & volume: Neurosci. Lett., 1999 Dec 24 , 277, 111-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10624822

Abstract
The structure of the gene encoding the human brain beta1 subunit of voltage dependent calcium channels (CACNB1) was determined by comparison of its genomic sequence with beta1 cDNA sequence. CACNB1 is distributed over 25 kb and contains 13 exons. Alternative splicing of CACNB1 RNA occurs within the central domain at exon 7, and the 3' domain at exon 13, producing the variably expressed beta1a, beta1b and beta1c isoforms. Exon/intron boundaries and exon lengths are conserved for the nine exons shared by the beta1 and related brain beta3 and beta4 genes.