Referenced in: none

Automatically associated channels: Kir2.3 , Kv6.2 , Kv6.3

Title: Expression of novel potassium channels in the chick basilar papilla.

Authors: K Mason, F V Peale, J S Stone, E W Rubel, M Bothwell

Journal, date & volume: Hear. Res., 1998 Nov , 125, 120-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9833966

Abstract
Ionic currents are critical for the functioning of the inner ear auditory sensory epithelium. We set out to identify and molecularly clone the genes encoding the channels responsible for several currents in the chick basilar papilla. Here we describe an inward-rectifying K+ channel, cKir2.3, present in both hair cells and support cells in the apical end of the chick basilar papilla. The biophysical properties of the human ortholog, hKir2.3, are similar to those of an inward-rectifying channel found in the apical end of the chick basilar papilla, suggesting that this channel may contribute to the corresponding current. Additionally, we describe two new members of the Kv6 subfamily of putative regulatory voltage-gated K channels, cKv6.2 and cKv6.3. Both are expressed in hair cells in the apical end of the chick basilar papilla; cKv6.2 is also strongly expressed in support cells and in the brain.